Article
Clinical impact of c-MET expression and mutational status in patients with colorectal cancer lung metastases.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery - 1 Apr 2016
Schweiger Thomas, Starkl Veronika, Glueck Olaf, Glogner Christoph, Traxler Denise, Jedamzik Julia, Liebmann-Reindl Sandra, Birner Peter, Streubel Berthold, Klepetko Walter, Hoetzenecker Konrad
Abstract excerpt
OBJECTIVES: The c-MET tyrosine kinase is known to play a key role in tumour promotion in a variety of cancers. The prognostic significance of c-MET pathway alterations has previously been described in primary colorectal cancer (CRC). However, data on the expression and genetic mutational status of c-MET in CRC pulmonary metastases (PM) are lacking. We aimed to assess the clinical implications of alterations in...
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