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Article

KRAS mutation in lung metastases from colorectal cancer: prognostic implications.

Cancer medicine - 1 Feb 2016

Ghidini Michele, Personeni Nicola, Bozzarelli Silvia, Baretti Marina, Basso Gianluca, Bianchi Paolo, Tronconi Maria Chiara, Pressiani Tiziana, Grizzi Fabio, Giordano Laura, Malesci Alberto, Alloisio Marco, Laghi Luigi, Santoro Armando, Rimassa Lorenza

Abstract excerpt

KRAS mutant colorectal cancer (CRC) patients develop lung and brain metastases more frequently than KRAS wild-type (WT) counterpart. We retrospectively investigated the prognostic role of KRAS, BRAF, and PIK3CA (exon 20) mutations and loss of phosphatase and tensin homolog (PTEN) in surgically resected lung metastases. Lung specimens from 75 metastatic CRC (mCRC) patients treated with one or more metastasectomies...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26715198
DOI: 10.1002/cam4.592
PMCID: PMC4735767

Genes

KRAS
PTEN
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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