Article
Inhaled corticosteroid treatment modulates ZNF432 gene variant's effect on bronchodilator response in asthmatics.
The Journal of allergy and clinical immunology - 1 Mar 2014
Wu Ann Chen, Himes Blanca E, Lasky-Su Jessica, Litonjua Augusto, Peters Stephen P, Lima John, Kubo Michiaki, Tamari Mayumi, Nakamura Yusuke, Qiu Weiliang, Weiss Scott T, Tantisira Kelan
Abstract excerpt
BACKGROUND: Single nucleotide polymorphisms (SNPs) influence a patient's response to inhaled corticosteroids and β2-agonists, and the effect of treatment with inhaled corticosteroids is synergistic with the effect of β2-agonists. We hypothesized that use of inhaled corticosteroids could influence the effect of SNPs associated with a bronchodilator response. OBJECTIVE: To assess whether, among subjects with...
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