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Article

Gene-by-environment effect of house dust mite on purinergic receptor P2Y12 (P2RY12) and lung function in children with asthma.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Feb 2012

Bunyavanich S, Boyce J A, Raby B A, Weiss S T

Abstract excerpt

BACKGROUND: Distinct receptors likely exist for leukotriene (LT)E(4), a potent mediator of airway inflammation. Purinergic receptor P2Y12 is needed for LTE(4)-induced airways inflammation, and P2Y12 antagonism attenuates house dust mite-induced pulmonary eosinophilia in mice. Although experimental data support a role for P2Y12 in airway inflammation, its role in human asthma has never been studied. OBJECTIVE: To...

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Identifiers

PMID: 22010907
DOI: 10.1111/j.1365-2222.2011.03874.x
PMCID: PMC3353543

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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