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Article

Affinity purification of human factor H on polypeptides derived from streptococcal m protein: enrichment of the Y402 variant.

PloS one - 1 Jan 2013

Nilsson O Rickard, Lannergård Jonas, Morgan B Paul, Lindahl Gunnar, Gustafsson Mattias C U

Abstract excerpt

Recent studies indicate that defective activity of complement factor H (FH) is associated with several human diseases, suggesting that pure FH may be used for therapy. Here, we describe a simple method to isolate human FH, based on the specific interaction between FH and the hypervariable region (HVR) of certain Streptococcus pyogenes M proteins. Special interest was focused on the FH polymorphism Y402H, which is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24278416
DOI: 10.1371/journal.pone.0081303
PMCID: PMC3836803

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Affinity purification of human factor H on polypeptides derived from streptococcal m protein: enrichment of the Y402 variant.PMID 24278416Read ↗

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