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Article

Role of the Hypervariable Region in Streptococcal M Proteins: Binding of a Human Complement Inhibitor

1 Nov 1998

Abstract excerpt

Antigenic variation allows pathogenic microorganisms to evade the immune system of the infected host. The variable structure must play an important role in pathogenesis, but its function is in most cases unknown. Here, we identify a function for the surface-exposed hypervariable region of streptococcal M5 protein, a virulence factor that inhibits phagocytosis. The hypervariable region of M5 was found to bind the...

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PMID: 9794423
DOI: 10.4049/jimmunol.161.9.4894

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Related research

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Role of the Hypervariable Region in Streptococcal M Proteins: Binding of a Human Complement InhibitorPMID 9794423Read ↗

Binding of human plasma proteins to Streptococcus pyogenes M protein determines the location of opsonic and non‐opsonic epitopesSemantic proximity Read ↗

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Isolated Hypervariable Regions Derived from Streptococcal M Proteins Specifically Bind Human C4b-Binding Protein: Implications for Antigenic VariationSemantic proximity Read ↗

Human C4BP binds to the hypervariable N-terminal region of many members in the streptococcal M protein family.Semantic proximity Read ↗

Binding of human C4BP to the hypervariable region of M protein: a molecular mechanism of phagocytosis resistance in Streptococcus pyogenes.Semantic proximity Read ↗

Human fibrinogen bound to Streptococcus pyogenes M protein inhibits complement deposition via the classical pathwaySemantic proximity Read ↗

Group A streptococci induce stronger M protein-fibronectin interaction when specific human antibodies are boundSemantic proximity Read ↗

Identification of a Domain in Human Factor H and Factor H-Like Protein-1 Required for the Interaction with Streptococcal M ProteinsSemantic proximity Read ↗

Extreme Sequence Divergence but Conserved Ligand-Binding Specificity in Streptococcus pyogenes M ProteinSemantic proximity Read ↗

Human C4b-binding Protein, Structural Basis for Interaction with Streptococcal M Protein, a Major Bacterial Virulence FactorSemantic proximity Read ↗

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