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Article

A highly variable region in members of the streptococcal M protein family binds the human complement regulator C4BP

1 Oct 1996

Abstract excerpt

Strains of Streptococcus pyogenes express one or more molecules that are members of the M protein family, a group of surface proteins implicated in virulence. A characteristic property of the molecules in this family is the presence of a highly variable N-terminal region, whose function is unknown. Here we show that human C4b-binding protein (C4BP), a regulatory component of the complement system, binds to the...

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Identifiers

PMID: 8816411
DOI: 10.4049/jimmunol.157.7.3021

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Related research

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A highly variable region in members of the streptococcal M protein family binds the human complement regulator C4BPPMID 8816411Read ↗

Human C4BP binds to the hypervariable N-terminal region of many members in the streptococcal M protein family.Semantic proximity Read ↗

Human C4b-binding Protein, Structural Basis for Interaction with Streptococcal M Protein, a Major Bacterial Virulence FactorSemantic proximity Read ↗

Human C4b-Binding Protein Has Overlapping, But Not Identical, Binding Sites for C4b and Streptococcal M ProteinsSemantic proximity Read ↗

Extreme Sequence Divergence but Conserved Ligand-Binding Specificity in Streptococcus pyogenes M ProteinSemantic proximity Read ↗

Isolated Hypervariable Regions Derived from Streptococcal M Proteins Specifically Bind Human C4b-Binding Protein: Implications for Antigenic VariationSemantic proximity Read ↗

Role of the Hypervariable Region in Streptococcal M Proteins: Binding of a Human Complement InhibitorSemantic proximity Read ↗

Ig-binding surface proteins of Streptococcus pyogenes also bind human C4b-binding protein (C4BP), a regulatory component of the complement system.Semantic proximity Read ↗

Conservation of C4BP-binding Sequence Patterns in <i>Streptococcus pyogenes</i> M and Enn ProteinsSemantic proximity Read ↗

Binding of human C4BP to the hypervariable region of M protein: a molecular mechanism of phagocytosis resistance in Streptococcus pyogenes.Semantic proximity Read ↗

Binding of human plasma proteins to Streptococcus pyogenes M protein determines the location of opsonic and non‐opsonic epitopesSemantic proximity Read ↗

A cluster of positively charged amino acids in the alpha-chain of C4b-binding protein (C4BP) is pivotal for the regulation of the complement system and the interaction with bacteria.Semantic proximity Read ↗

Streptococcal M proteins and their role as virulence determinantsSemantic proximity Read ↗

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