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Article

Production of biologically active complement factor H in therapeutically useful quantities.

Protein expression and purification - 1 Apr 2011

Schmidt Christoph Q, Slingsby Fern C, Richards Anna, Barlow Paul N

Abstract excerpt

Human complement factor H (FH), an abundant 155-kDa plasma glycoprotein with 40 disulphide bonds, regulates the alternative-pathway complement cascade. Mutations and single nucleotide polymorphisms in the FH gene predispose to development of age-related macular degeneration, atypical haemolytic uraemic syndrome and dense deposit disease. Supplementation with FH variants protective against disease is an enticing...

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Identifiers

PMID: 21146613
DOI: 10.1016/j.pep.2010.12.002
PMCID: PMC4067574

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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