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Article

Complement factor H allotype 402H is associated with increased C3b opsonization and phagocytosis of Streptococcus pyogenes.

Molecular microbiology - 1 Nov 2008

Haapasalo Karita, Jarva Hanna, Siljander Tuula, Tewodros Wezenet, Vuopio-Varkila Jaana, Jokiranta T Sakari

Abstract excerpt

The main virulence factor of group A streptococcus (GAS), M protein, binds plasma complement regulators factor H (FH) and FH-like protein 1 (FHL-1) leading to decreased opsonization. The M protein binding site on FH is within domain 7 in which also the age-related macular degeneration (AMD)-assoc...

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Identifiers

PMID: 18627465
DOI: 10.1111/j.1365-2958.2008.06347.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18627465-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Complement factor H allotype 402H is associated with increased C3b opsonization and phagocytosis of Streptococcus pyogenes.PMID 18627465Read ↗

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