Article
Adenylyl cyclase 6 mediates loading-induced bone adaptation in vivo.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Mar 2014
Lee Kristen L, Hoey David A, Spasic Milos, Tang Tong, Hammond H Kirk, Jacobs Christopher R
Abstract excerpt
Primary cilia are single, nonmotile, antenna-like structures extending from the apical membrane of most mammalian cells. They may mediate mechanotransduction, the conversion of external mechanical stimuli into biochemical intracellular signals. Previously we demonstrated that adenylyl cyclase 6 (AC6), a membrane-bound enzyme enriched in primary cilia of MLO-Y4 osteocyte-like cells, may play a role in a primary...
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