Article
Inactivation of Lrp5 in osteocytes reduces young's modulus and responsiveness to the mechanical loading.
Bone - 1 May 2013
Zhao Liming, Shim Joon W, Dodge Todd R, Robling Alexander G, Yokota Hiroki
Abstract excerpt
Low-density-lipoprotein receptor-related protein 5 (Lrp5) is a co-receptor in Wnt signaling, which plays a critical role in development and maintenance of bone. Osteoporosis-pseudoglioma syndrome, for instance, arises from loss-of-function mutations in Lrp5, and global deletion of Lrp5 in mice results in significantly lower bone mineral density. Since osteocytes are proposed to act as a mechanosensor in the bone,...
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