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Article

BCL6 suppression of BCL2 via Miz1 and its disruption in diffuse large B cell lymphoma.

Proceedings of the National Academy of Sciences of the United States of America - 7 Jul 2009

Saito Masumichi, Novak Urban, Piovan Erich, Basso Katia, Sumazin Pavel, Schneider Christof, Crespo Marta, Shen Qiong, Bhagat Govind, Califano Andrea, Chadburn Amy, Pasqualucci Laura, Dalla-Favera Riccardo

Abstract excerpt

The BCL6 proto-oncogene encodes a transcriptional repressor that is required for germinal center (GC) formation and whose deregulation by genomic lesions is implicated in the pathogenesis of GC-derived diffuse large B cell lymphoma (DLBCL) and, less frequently, follicular lymphoma (FL). The biological function of BCL6 is only partially understood because no more than a few genes have been functionally...

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Topics

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Share to B-Lymphocytes
Share to Germinal Center

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphoma, Large B-Cell, Diffuse

Share to Proto-Oncogene Mas

Share to Proto-Oncogene Proteins c-bcl-2

Share to Proto-Oncogene Proteins c-bcl-6

Share to Somatic Hypermutation, Immunoglobulin

Share to Translocation, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 19549844
DOI: 10.1073/pnas.0903854106
PMCID: PMC2708681

Genes

BCL2
BCL6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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