Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Spontaneous generation of infectious prion disease in transgenic mice.

Emerging infectious diseases - 1 Dec 2013

Torres Juan-María, Castilla Joaquín, Pintado Belén, Gutiérrez-Adan Alfonso, Andréoletti Olivier, Aguilar-Calvo Patricia, Arroba Ana-Isabel, Parra-Arrondo Beatriz, Ferrer Isidro, Manzanares Jorge, Espinosa Juan-Carlos

Abstract excerpt

We generated transgenic mice expressing bovine cellular prion protein (PrP(C)) with a leucine substitution at codon 113 (113L). This protein is homologous to human protein with mutation 102L, and its genetic link with Gerstmann-Sträussler-Scheinker syndrome has been established. This mutation in bovine PrP(C) causes a fully penetrant, lethal, spongiform encephalopathy. This genetic disease was transmitted by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to Cattle

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Encephalopathy, Bovine Spongiform

Share to Hippocampus

Share to Mice, Transgenic

Share to Open Reading Frames

Share to Prion Diseases

Share to PrPSc Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 24274622
DOI: 10.3201/eid1912.130106
PMCID: PMC3840888

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spontaneous generation of infectious prion disease in transgenic mice.PMID 24274622Read ↗

Spontaneous neurodegeneration in transgenic mice with mutant prion protein.Semantic proximity Read ↗

Review: contribution of transgenic models to understanding human prion disease.Semantic proximity Read ↗

Genetic and infectious prion diseases.Semantic proximity Read ↗

Transgenic analysis of prion diseases.Semantic proximity Read ↗

Transgenetic investigations of prion diseases of humans and animals.Semantic proximity Read ↗

Presumptive BSE cases with an aberrant prion protein phenotype in Switzerland, 2011: Lack of prion disease in experimentally inoculated cattle and bovine prion protein transgenic mice.Semantic proximity Read ↗

Interactions between wild-type and mutant prion proteins modulate neurodegeneration in transgenic mice.Semantic proximity Read ↗

Human prion strain selection in transgenic mice.Semantic proximity Read ↗

PrP aggregation can be seeded by pre-formed recombinant PrP amyloid fibrils without the replication of infectious prions.Semantic proximity Read ↗

A single amino acid alteration (101L) introduced into murine PrP dramatically alters incubation time of transmissible spongiform encephalopathy.Semantic proximity Read ↗

Transgenic mice expressing bovine PrP with a four extra repeat octapeptide insert mutation show a spontaneous, non-transmissible, neurodegenerative disease and an expedited course of BSE infection.Semantic proximity Read ↗

Human prion protein with valine 129 prevents expression of variant CJD phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.