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Article

Spontaneous neurodegeneration in transgenic mice with mutant prion protein.

Science (New York, N.Y.) - 14 Dec 1990

Hsiao K K, Scott M, Foster D, Groth D F, DeArmond S J, Prusiner S B

Abstract excerpt

Transgenic mice were created to assess genetic linkage between Gerstmann-Sträussler-Scheinker syndrome and a leucine substitution at codon 102 of the human prion protein gene. Spontaneous neurologic disease with spongiform degeneration and gliosis similar to that in mouse scrapie developed at a m...

Topics

Amino Acid Sequence
Animals
Base Sequence
Brain
Brain Diseases
Codon
DNA
Disease Models, Animal
Endopeptidase K
Gerstmann-Straussler-Scheinker Disease
Leucine
Mice
Mice, Transgenic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Nucleic Acid Hybridization

Pedigree

PrPSc Proteins

Source

Identifiers

PMID: 1980379
DOI: 10.1126/science.1980379

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1980379-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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