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Article

Cyclophilin B supports Myc and mutant p53-dependent survival of glioblastoma multiforme cells.

Cancer research - 15 Jan 2014

Choi Jae Won, Schroeder Mark A, Sarkaria Jann N, Bram Richard J

Abstract excerpt

Glioblastoma multiforme is an aggressive, treatment-refractory type of brain tumor for which effective therapeutic targets remain important to identify. Here, we report that cyclophilin B (CypB), a prolyl isomerase residing in the endoplasmic reticulum (ER), provides an essential survival signal in glioblastoma multiforme cells. Analysis of gene expression databases revealed that CypB is upregulated in many cases...

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Source

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Identifiers

PMID: 24272483
DOI: 10.1158/0008-5472.CAN-13-0771
PMCID: PMC3935234

Genes

MYC
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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