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Article

Neuroprotective effects of overexpressed cyclophilin B against Aβ-induced neurotoxicity in PC12 cells.

Free radical biology & medicine - 15 Aug 2011

Oh Yoojung, Kim Eun Young, Kim Yeonghwan, Jin Jizi, Jin Byung Kwan, Jahng Geon-Ho, Jung Min Hyung, Park Chan, Kang Insug, Ha Joohun, Choe Wonchae

Abstract excerpt

Accumulated amyloid-β (Aβ) is a well-known cause of neuronal apoptosis in Alzheimer disease and functions in part by generating oxidative stress. Our previous work suggested that cyclophilin B (CypB) protects against endoplasmic reticulum (ER) stress. Therefore, in this study we examined the ability of CypB to protect against Aβ toxicity. CypB is present in the neurons of rat and mouse brains, and treating neural...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21683784
DOI: 10.1016/j.freeradbiomed.2011.05.036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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