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Article

ROS-p53-cyclophilin-D signaling mediates salinomycin-induced glioma cell necrosis

29 May 2015

Abstract excerpt

BACKGROUND: The primary glioblastoma multiforme (GBM) is the most malignant form of astrocytic tumor with an average survival of approximately 12-14 months. The search for novel and more efficient chemo-agents against this disease is urgent. Salinomycin induces broad anti-cancer effects; however, its role in GBM and the underlying mechanism are not clear. RESULTS: Here we found that salinomycin induced both...

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PMID: 26024660
DOI: 10.1186/s13046-015-0174-1

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