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Article

CHOP and caspase 3 induction underlie glioblastoma cell death in response to endoplasmic reticulum stress

19 Dec 2011

Abstract excerpt

The unfolded protein endoplasmic reticulum stress response has emerged as a cellular physiological target to invoke tumor cell killing due to its homeostatic and cytoprotective functions. In this study, thapsigargin and tunicamycin, two endoplasmic reticulum stress inducers, were investigated for their efficacy on glioblastomas. We demonstrate that clinically relevant concentrations of thapsigargin and...

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Identifiers

PMID: 22969916
DOI: 10.3892/etm.2011.422

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