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Coiled-coil domain containing 109B is a HIF1α-regulated gene critical for progression of human gliomas

28 Jul 2017

Abstract excerpt

BACKGROUND: The coiled-coil domain is a structural motif found in proteins that participate in a variety of biological processes. Aberrant expression of such proteins has been shown to be associated with the malignant behavior of human cancers. In this study, we investigated the role of a specific family member, coiled-coil domain containing 109B (CCDC109B), in human gliomas. METHODS AND RESULTS: We confirmed...

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PMID: 28754121
DOI: 10.1186/s12967-017-1266-9

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