Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cyclophilin B induces chemoresistance by degrading wild‐type p53 via interaction with MDM2 in colorectal cancer

7 Jun 2018

Abstract excerpt

Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. Chemoresistance is a major problem for effective therapy in CRC. Here, we investigated the mechanism by which peptidylprolyl isomerase B (PPIB; cyclophilin B, CypB) regulates chemoresistance in CRC. We found that CypB is a novel wild-type p53 (p53WT)-inducible gene but a negative regulator of p53WT in response to oxaliplatin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Mechanisms and Therapy
Share to PARP inhibition in cancer therapy
Share to Signaling Pathways in Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29876924
DOI: 10.1002/path.5107

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cyclophilin B induces chemoresistance by degrading wild‐type p53 via interaction with MDM2 in colorectal cancerPMID 29876924Read ↗

The Regulation of p53 by Ubiquitination and Implications for Therapeutic Targeting in Colorectal Cancer.Semantic proximity Read ↗

Pleckstrin homology domain-containing protein PHLDB3 supports cancer growth via a negative feedback loop involving p53.Semantic proximity Read ↗

Cyclophilin B supports Myc and mutant p53-dependent survival of glioblastoma multiforme cells.Semantic proximity Read ↗

USP10/XAB2/ANXA2 axis promotes DNA damage repair to enhance chemoresistance to oxaliplatin in colorectal cancerSemantic proximity Read ↗

Pathogenesis of colorectal carcinoma and therapeutic implications: the roles of the ubiquitin–proteasome system and Cox‐2Semantic proximity Read ↗

c-MYC-USP49-BAG2 axis promotes proliferation and chemoresistance of colorectal cancer cells in vitroSemantic proximity Read ↗

miR-92b-3p Regulates Cell Cycle and Apoptosis by Targeting CDKN1C, Thereby Affecting the Sensitivity of Colorectal Cancer Cells to Chemotherapeutic DrugsSemantic proximity Read ↗

EPLIN, a Putative Tumour Suppressor in Colorectal Cancer, Implications in Drug ResistanceSemantic proximity Read ↗

DPEP1 promotes drug resistance in colon cancer cells by forming a positive feedback loop with ASCL2Semantic proximity Read ↗

Squalene epoxidase/SQLE is a candidate target for treatment of colorectal cancers with p53 mutation and elevated c-MYC expression.Semantic proximity Read ↗

FBX8 degrades GSTP1 through ubiquitination to suppress colorectal cancer progressionSemantic proximity Read ↗

PRDX2 promotes the proliferation of colorectal cancer cells by increasing the ubiquitinated degradation of p53Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.