Status of CHEK2 and p53 in patients with early‑onset and conventional gastric cancer

Abstract excerpt

Gastric cancer (GC) is the fourth most common cause of cancer‑associated death. Based on the age at diagnosis, GC is divided into early‑onset GC (EOGC; ≤45 years) and conventional GC (CGC; >45 years). Mutations in the cell cycle checkpoint kinase 2 (CHEK2) and TP53 genes are associated with several types of cancer; however, their genetic defects in GC remain poorly understood. The aim of the present study was to...

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