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Article

A genome-wide study of gastric intramucosal neoplasia based on somatic copy number alterations, gene mutations, and mRNA expression patterns.

The journal of pathology. Clinical research - 1 Mar 2024

Koike Yoshihiko, Osakabe Mitsumasa, Sugimoto Ryo, Uesugi Noriyuku, Matsumoto Takayuki, Suzuki Hiromu, Yanagawa Naoki, Sugai Tamotsu

Abstract excerpt

We performed comprehensive analyses of somatic copy number alterations (SCNAs) and gene expression profiles of gastric intramucosal neoplasia (IMN) using array-based methods in 97 intestinal-type IMNs, including 39 low-grade dysplasias (LGDs), 37 high-grade dysplasias (HGDs), and 26 intramucosal carcinomas (IMCs) with stromal invasion of the lamina propria to identify the molecular mechanism of IMN. In addition,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38454538
DOI: 10.1002/2056-4538.12368
PMCID: PMC10920940

Genes

HGD
TP53

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