Article
yciM is an essential gene required for regulation of lipopolysaccharide synthesis in Escherichia coli.
Molecular microbiology - 1 Jan 2014
Mahalakshmi S, Sunayana M R, SaiSree L, Reddy Manjula
Abstract excerpt
The outer membrane of Gram-negative bacteria is an asymmetric lipid bilayer consisting of an essential glycolipid lipopolysaccharide (LPS) in its outer leaflet and phospholipids in the inner leaflet. Here, we show that yciM, a gene encoding a tetratricopeptide repeat protein of unknown function, modulates LPS levels by negatively regulating the biosynthesis of lipid A, an essential constituent of LPS....
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