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Article

Assembly of lipopolysaccharide in Escherichia coli requires the essential LapB heat shock protein.

The Journal of biological chemistry - 23 May 2014

Klein Gracjana, Kobylak Natalia, Lindner Buko, Stupak Anna, Raina Satish

Abstract excerpt

Here, we describe two new heat shock proteins involved in the assembly of LPS in Escherichia coli, LapA and LapB (lipopolysaccharide assembly protein A and B). lapB mutants were identified based on an increased envelope stress response. Envelope stress-responsive pathways control key steps in LPS biogenesis and respond to defects in the LPS assembly. Accordingly, the LPS content in ΔlapB or Δ(lapA lapB) mutants...

Topics

ATP-Dependent Proteases
Amidohydrolases
Base Sequence
Blotting, Western
Cell Membrane
Escherichia coli
Escherichia coli Proteins
Gene Expression Regulation, Bacterial
Genes, Essential
Glycosyltransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HSP70 Heat-Shock Proteins

Heat-Shock Proteins

Hot Temperature

Lipopolysaccharides

Membrane Proteins

Models, Molecular

Molecular Sequence Data

Molecular Structure

Source

Open in PubMed Open full text

Identifiers

PMID: 24722986
DOI: 10.1074/jbc.M113.539494
PMCID: PMC4031536

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-24722986-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Assembly of lipopolysaccharide in Escherichia coli requires the essential LapB heat shock protein.PMID 24722986Read ↗

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