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Article

The inner membrane protein LapB is required for adaptation to cold stress in an LpxC-independent manner.

Journal of microbiology (Seoul, Korea) - 1 Jul 2021

Lee Han Byeol, Park Si Hyoung, Lee Chang-Ro

Abstract excerpt

The inner membrane protein lipopolysaccharide assembly protein B (LapB) is an adaptor protein that activates the proteolysis of LpxC by an essential inner membrane metalloprotease, FtsH, leading to a decrease in the level of lipopolysaccharide in the membrane. In this study, we revealed the mechanism by which the essential inner membrane protein YejM regulates LapB and analyzed the role of the transmembrane...

Topics

Adaptation, Physiological
Amidohydrolases
Cold-Shock Response
Escherichia coli
Escherichia coli Proteins
Lipopolysaccharides
Membrane Proteins
Mutation
Protein Domains
Proteolysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33990910
DOI: 10.1007/s12275-021-1130-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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