Dual function of LapB (YciM) in regulating Escherichia coli lipopolysaccharide synthesis.

doi:10.1073/pnas.2321510121

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Article

Dual function of LapB (YciM) in regulating Escherichia coli lipopolysaccharide synthesis.

Proceedings of the National Academy of Sciences of the United States of America - 23 Apr 2024

Shu Sheng, Tsutsui Yuko, Nathawat Rajkanwar, Mi Wei

Abstract excerpt

Levels of lipopolysaccharide (LPS), an essential glycolipid on the surface of most gram-negative bacteria, are tightly controlled-making LPS synthesis a promising target for developing new antibiotics. Escherichia coli adaptor protein LapB (YciM) plays an important role in regulating LPS synthesis by promoting degradation of LpxC, a deacetylase that catalyzes the first committed step in LPS synthesis. Under...

Topics

Escherichia coli
Lipopolysaccharides
Escherichia coli Proteins
Mutation
Rubredoxins
Amidohydrolases
Membrane Proteins

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Identifiers

PMID: 38635633
DOI: 10.1073/pnas.2321510121
PMCID: PMC11046580

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