Article
The polymorphisms of T cell-specific TBX21 gene may contribute to the susceptibility of chronic immune thrombocytopenia in Chinese population.
Human immunology - 1 Feb 2014
Zhang Donglei, Zhang Xian, Ge Meili, Xuan Min, Li Huiyuan, Yang Yanhui, Fu Rongfeng, Zhou Fangfang, Zheng Yizhou, Yang Renchi
Abstract excerpt
Chronic primary immune thrombocytopenia (ITP) is an acquired autoimmune hemorrhagic disease characterized by both reduced platelet counts and suppression of megakaryocyte and platelet development. T cell-specific T-box transcription factor gene (TBX21) plays a critical role in the development and maintenance of T helper 1 (Th1) cells. Recently, several studies have confirmed that the T-1554C and T-1993C...
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