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Article

PTPN22 gene polymorphism as a genetic risk factor for primary immune thrombocytopenia in Egyptian children.

Expert review of hematology - 1 Sept 2021

Hesham Mervat, Hassan Tamer, Fawzy Amal, Mohamed Noura, Alhejny Ebtihaj, Fathy Manar, El Gebaly Sherief, Zakaria Marwa

Abstract excerpt

OBJECTIVES: Several genetic and non-genetic risk factors are implicated in the etiology and pathogenesis of primary immune thrombocytopenia (ITP). Protein tyrosine phosphatase non-receptor 22 gene (PTPN22) plays an important role in regulation of signal transduction through the T-cell receptors. PTPN22 1858 C > T single nucleotide polymorphism was reported to be associated with increased risk of autoimmune...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genetic Predisposition to Disease

Share to Polymorphism, Single Nucleotide

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 22

Share to Purpura, Thrombocytopenic, Idiopathic

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Source

Identifiers

PMID: 33064968
DOI: 10.1080/17474086.2020.1838895

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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