Article
The polymorphisms of tumor necrosis factor-induced protein 3 gene may contribute to the susceptibility of chronic primary immune thrombocytopenia in Chinese population.
Platelets - 1 Jan 2016
Zhou Hu, Yang Jingyi, Liu Liu, Zhang Donglei, Zhou Keshu, Li Huiyuan, Zhao Huifang, Han Lijie, Zhou Jian, Liu Xinjian, Song Yongping, Yang Renchi
Abstract excerpt
Primary immune thrombocytopenia (ITP) is an acquired autoimmune disease characterized by decrease of the platelet count and increased risk of mucocutaneous bleeding. Multiple factors have been demonstrated in ITP pathogenesis, including the genetic variants. Tumor necrosis factor-induced protein 3 (TNFAIP3) gene encodes the ubiquitin-modifying enzyme A20 which limits inflammation by terminating NF-κB activation...
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