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Article

A novel inhibitor of the insulin/IGF signaling pathway protects from age‐onset, neurodegeneration‐linked proteotoxicity

22 Nov 2013

Abstract excerpt

Aging manipulation is an emerging strategy aimed to postpone the manifestation of late-onset neurodegenerative disorders such as Alzheimer's (AD) and Huntington's diseases (HD) and to slow their progression once emerged. Reducing the activity of the insulin/IGF signaling cascade (IIS), a prominent aging-regulating pathway, protects worms from proteotoxicity of various aggregative proteins, including the...

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Share to Cholinesterase and Neurodegenerative Diseases
Share to Genetics, Aging, and Longevity in Model Organisms
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PMID: 24261972
DOI: 10.1111/acel.12171

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