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Article

A CTLA4high genotype is associated with myasthenia gravis in thymoma patients.

Annals of neurology - 1 Oct 2005

Chuang Wen-Yu, Ströbel Philipp, Gold Ralf, Nix Wilfred, Schalke Berthold, Kiefer Reinhard, Opitz Andreas, Klinker Erdwine, Müller-Hermelink Hans K, Marx Alexander

Abstract excerpt

Myasthenia gravis (MG) in thymoma patients depends critically on intratumorous generation and export of mature autoreactive CD4+ T cells. Why non-MG thymomas fail to produce CD4+ T cells is unknown. We studied three single-nucleotide polymorphisms of the cytotoxic T-lymphocyte-associated antigen 4(CTLA4) gene in thymoma patients, nonthymoma early-onset MG patients, and control subjects. Surprisingly, the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16178018
DOI: 10.1002/ana.20577

Genes

CTLA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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