Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A CTLA4high genotype is associated with myasthenia gravis in thymoma patients.

Annals of neurology - 1 Oct 2005

Chuang Wen-Yu, Ströbel Philipp, Gold Ralf, Nix Wilfred, Schalke Berthold, Kiefer Reinhard, Opitz Andreas, Klinker Erdwine, Müller-Hermelink Hans K, Marx Alexander

Abstract excerpt

Myasthenia gravis (MG) in thymoma patients depends critically on intratumorous generation and export of mature autoreactive CD4+ T cells. Why non-MG thymomas fail to produce CD4+ T cells is unknown. We studied three single-nucleotide polymorphisms of the cytotoxic T-lymphocyte-associated antigen...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD
Share to Antigens, Differentiation
Share to CTLA-4 Antigen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Demography

Share to Gene Frequency

Share to Myasthenia Gravis

Share to Thymoma

Share to Thymus Neoplasms

Source

Identifiers

PMID: 16178018
DOI: 10.1002/ana.20577

Genes

CTLA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16178018-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A CTLA4high genotype is associated with myasthenia gravis in thymoma patients.PMID 16178018Read ↗

Late-onset myasthenia gravis - CTLA4(low) genotype association and low-for-age thymic output of naïve T cells.Semantic proximity Read ↗

Elucidating genetic backgrounds of myasthenia gravis in Japanese by genome-wide association studies and multi-omics analyses of thymoma.Semantic proximity Read ↗

Genetic association of Ctla-4 to myasthenia gravis with thymoma.Semantic proximity Read ↗

CTLA4 variants and haplotype contribute genetic susceptibility to myasthenia gravis in northern Chinese population.Semantic proximity Read ↗

Myasthenia gravis-specific aberrant neuromuscular gene expression by medullary thymic epithelial cells in thymomaSemantic proximity Read ↗

A pathogenetic role for the thymoma in myasthenia gravis. Autosensitization of IL-4- producing T cell clones recognizing extracellular acetylcholine receptor epitopes presented by minority class II isotypes.Semantic proximity Read ↗

Myasthenia gravis-specific aberrant neuromuscular gene expression by medullary thymic epithelial cells in thymomaSemantic proximity Read ↗

Association of the DNMT3B -579G>T polymorphism with risk of thymomas in patients with myasthenia gravis.Semantic proximity Read ↗

The PTPN22gain-of-function+1858T(+) genotypes correlate with low IL-2 expression in thymomas and predispose to myasthenia gravis.Semantic proximity Read ↗

CDS1 and promoter single nucleotide polymorphisms of the CTLA-4 gene in human myasthenia gravis.Semantic proximity Read ↗

Pathomechanisms of paraneoplastic myasthenia gravis.Semantic proximity Read ↗

Is the Myasthenia Gravis (MG) the Result of Age and Sex/Gender? A Narrative Review for Identifying Genetic and Epigenetic Biomarkers for a Differential MG Management in Old and Young WomenSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.