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Article

Development and implementation of a high-throughput compound screening assay for targeting disrupted ER calcium homeostasis in Alzheimer's disease.

PloS one - 1 Jan 2013

Honarnejad Kamran, Daschner Alexander, Giese Armin, Zall Andrea, Schmidt Boris, Szybinska Aleksandra, Kuznicki Jacek, Herms Jochen

Abstract excerpt

Disrupted intracellular calcium homeostasis is believed to occur early in the cascade of events leading to Alzheimer's disease (AD) pathology. Particularly familial AD mutations linked to Presenilins result in exaggerated agonist-evoked calcium release from endoplasmic reticulum (ER). Here we report the development of a fully automated high-throughput calcium imaging assay utilizing a genetically-encoded...

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Identifiers

PMID: 24260442
DOI: 10.1371/journal.pone.0080645
PMCID: PMC3829862

Genes

BACE1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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