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Article

Novel Selective Calpain 1 Inhibitors as Potential Therapeutics in Alzheimer's Disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2016

Fà Mauro, Zhang Hong, Staniszewski Agnieszka, Saeed Faisal, Shen Li W, Schiefer Isaac T, Siklos Marton I, Tapadar Subhasish, Litosh Vladislav A, Libien Jenny, Petukhov Pavel A, Teich Andrew F, Thatcher Gregory R J, Arancio Ottavio

Abstract excerpt

Alzheimer's disease, one of the most important brain pathologies associated with neurodegenerative processes, is related to overactivation of calpain-mediated proteolysis. Previous data showed a compelling efficacy of calpain inhibition against abnormal synaptic plasticity and memory produced by the excess of amyloid-β, a distinctive marker of the disease. Moreover, a beneficial effect of calpain inhibitors in...

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Identifiers

PMID: 26484927
DOI: 10.3233/JAD-150618
PMCID: PMC8962836

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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