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Article

Enhanced ROS generation mediated by Alzheimer's disease presenilin regulation of InsP3R Ca2+ signaling.

Antioxidants & redox signaling - 1 Apr 2011

Müller Marioly, Cheung King-Ho, Foskett J Kevin

Abstract excerpt

Familial Alzheimer's disease (FAD) is caused by mutations in amyloid precursor protein and presenilins (PS1, PS2). Many FAD-linked PS mutations affect intracellular calcium (Ca(2+)) homeostasis by proximal mechanisms independent of amyloid production by dramatically enhancing gating of the inositol trisphosphate receptor (InsP(3)R) intracellular Ca(2+) release channel by a gain-of-function effect that mirrors...

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Identifiers

PMID: 20701429
DOI: 10.1089/ars.2010.3421
PMCID: PMC3048838

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