Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Catechol-O-methyltransferase (COMT) genotype moderates the effects of childhood trauma on cognition and symptoms in schizophrenia.

Journal of psychiatric research - 1 Feb 2014

Green Melissa J, Chia T-Yunn, Cairns Murray J, Wu Jingqin, Tooney Paul A, Scott Rodney J, Carr Vaughan J

Abstract excerpt

The interaction of genetic and environmental factors may affect the course and development of psychotic disorders. We examined whether the effects of childhood trauma on cognition and symptoms in schizophrenia were moderated by the Catechol-O-methyltransferase (COMT) Val(158)Met polymorphism, a common genetic variant known to affect cognition and prefrontal dopamine levels. Participants were 429...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catechol O-Methyltransferase
Share to Child Abuse

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cognition Disorders

Share to Neuropsychological Tests

Share to Psychiatric Status Rating Scales

Share to Schizophrenia

Share to Schizophrenic Psychology

Share to Surveys and Questionnaires

Source

Identifiers

PMID: 24252819
DOI: 10.1016/j.jpsychires.2013.10.018

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Catechol-O-methyltransferase (COMT) genotype moderates the effects of childhood trauma on cognition and symptoms in schizophrenia.PMID 24252819Read ↗

Catechol-o-methyltransferase genotype and childhood trauma may interact to impact schizotypal personality traits.Semantic proximity Read ↗

The effect of COMT Val158Met and DRD2 C957T polymorphisms on executive function and the impact of early life stress.Semantic proximity Read ↗

The divergent impact of catechol-O-methyltransferase (COMT) Val158Met genetic polymorphisms on executive function in adolescents with discrete patterns of childhood adversity.Semantic proximity Read ↗

The effect of childhood maltreatment and cannabis use on adult psychotic symptoms is modified by the COMT Val¹⁵⁸Met polymorphism.Semantic proximity Read ↗

Interactions Between Early Trauma and Catechol-O-Methyltransferase Genes on Inhibitory Deficits in Children With ADHD.Semantic proximity Read ↗

The relationship between childhood abuse and dissociation. Is it influenced by catechol-O-methyltransferase (COMT) activity?Semantic proximity Read ↗

Evaluation of the association COMT Val158Met variant and childhood trauma on aggression in Turkish SCZ patients.Semantic proximity Read ↗

Relationship between the COMT-Val158Met and BDNF-Val66Met polymorphisms, childhood trauma and psychotic experiences in an adolescent general population sample.Semantic proximity Read ↗

Psychosis-inducing effects of cannabis are related to both childhood abuse and COMT genotypes.Semantic proximity Read ↗

Exploring the indirect effects of catechol-O-methyltransferase (COMT) genotype on psychotic experiences through cognitive function and anxiety disorders in a large birth cohort of children.Semantic proximity Read ↗

Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia.Semantic proximity Read ↗

Serotonin transporter gene polymorphism, childhood trauma, and cognition in patients with psychotic disorders.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.