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Article

Serotonin transporter gene polymorphism, childhood trauma, and cognition in patients with psychotic disorders.

Schizophrenia bulletin - 1 Jan 2012

Aas Monica, Djurovic Srdjan, Athanasiu Lavinia, Steen Nils Eiel, Agartz Ingrid, Lorentzen Steinar, Sundet Kjetil, Andreassen Ole A, Melle Ingrid

Abstract excerpt

OBJECTIVE: The functional polymorphism in the promoter region of the SLC6A4/5-HTT serotonin transporter gene (5-HTTLPR) has been linked to altered stress response. Carriers of the short (s-) allele have increased negative psychological reactions and stress hormone release compared with carriers of the long (l-) allele, interacting with severe life events including childhood trauma. High stress levels are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21908796
DOI: 10.1093/schbul/sbr113
PMCID: PMC3245595

Genes

HTT

Provenance

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