Article
A randomized trial of genotype-guided dosing of acenocoumarol and phenprocoumon.
The New England journal of medicine - 12 Dec 2013
Verhoef Talitha I, Ragia Georgia, de Boer Anthonius, Barallon Rita, Kolovou Genovefa, Kolovou Vana, Konstantinides Stavros, Le Cessie Saskia, Maltezos Efstratios, van der Meer Felix J M, Redekop William K, Remkes Mary, Rosendaal Frits R, van Schie Rianne M F, Tavridou Anna, Tziakas Dimitrios, Wadelius Mia, Manolopoulos Vangelis G, Maitland-van der Zee Anke H
Abstract excerpt
BACKGROUND: Observational evidence suggests that the use of a genotype-guided dosing algorithm may increase the effectiveness and safety of acenocoumarol and phenprocoumon therapy. METHODS: We conducted two single-blind, randomized trials comparing a genotype-guided dosing algorithm that included clinical variables and genotyping for CYP2C9 and VKORC1 with a dosing algorithm that included only clinical variables,...
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