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Article

A type 1 diabetes genetic risk score can discriminate monogenic autoimmunity with diabetes from early-onset clustering of polygenic autoimmunity with diabetes.

Diabetologia - 1 Apr 2018

Johnson Matthew B, Patel Kashyap A, De Franco Elisa, Houghton Jayne A L, McDonald Timothy J, Ellard Sian, Flanagan Sarah E, Hattersley Andrew T

Abstract excerpt

AIMS/HYPOTHESIS: Identifying individuals suitable for monogenic autoimmunity testing and gene discovery studies is challenging: early-onset type 1 diabetes mellitus can cluster with additional autoimmune diseases due to shared polygenic risk and islet- and other organ-specific autoantibodies are present in both monogenic and polygenic aetiologies. We aimed to assess whether a type 1 diabetes genetic risk score...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29417186
DOI: 10.1007/s00125-018-4551-0
PMCID: PMC6448971

Genes

AIRE
FOXP3
LRBA
STAT1
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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