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Article

Novel genetic risk factors influence progression of islet autoimmunity to type 1 diabetes.

Scientific reports - 5 Nov 2020

Onengut-Gumuscu Suna, Paila Umadevi, Chen Wei-Min, Ratan Aakrosh, Zhu Zhennan, Steck Andrea K, Frohnert Brigitte I, Waugh Kathleen C, Webb-Robertson Bobbie-Jo M, Norris Jill M, Lange Leslie A, Rewers Marian J, Rich Stephen S

Abstract excerpt

Type 1 diabetes arises from the autoimmune destruction of insulin-producing beta-cells of the pancreas, resulting in dependence on exogenously administered insulin to maintain glucose homeostasis. In this study, our aim was to identify genetic risk factors that contribute to progression from islet autoimmunity to clinical type 1 diabetes. We analyzed 6.8 million variants derived from whole genome sequencing of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33154504
DOI: 10.1038/s41598-020-75690-6
PMCID: PMC7645414

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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