Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes: A prospective study in children.

doi:10.1371/journal.pmed.1002548

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Article

Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes: A prospective study in children.

PLoS medicine - 1 Apr 2018

Bonifacio Ezio, Beyerlein Andreas, Hippich Markus, Winkler Christiane, Vehik Kendra, Weedon Michael N, Laimighofer Michael, Hattersley Andrew T, Krumsiek Jan, Frohnert Brigitte I, Steck Andrea K, Hagopian William A, Krischer Jeffrey P, Lernmark Åke, Rewers Marian J, She Jin-Xiong, Toppari Jorma, Akolkar Beena, Oram Richard A, Rich Stephen S, Ziegler Anette-G

Abstract excerpt

BACKGROUND: Around 0.3% of newborns will develop autoimmunity to pancreatic beta cells in childhood and subsequently develop type 1 diabetes before adulthood. Primary prevention of type 1 diabetes will require early intervention in genetically at-risk infants. The objective of this study was to determine to what extent genetic scores (two previous genetic scores and a merged genetic score) can improve the...

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PMID: 29614081
DOI: 10.1371/journal.pmed.1002548
PMCID: PMC5882115

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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