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Article

A Type 1 Diabetes Genetic Risk Score Predicts Progression of Islet Autoimmunity and Development of Type 1 Diabetes in Individuals at Risk.

Diabetes care - 1 Sept 2018

Redondo Maria J, Geyer Susan, Steck Andrea K, Sharp Seth, Wentworth John M, Weedon Michael N, Antinozzi Peter, Sosenko Jay, Atkinson Mark, Pugliese Alberto, Oram Richard A

Abstract excerpt

OBJECTIVE: We tested the ability of a type 1 diabetes (T1D) genetic risk score (GRS) to predict progression of islet autoimmunity and T1D in at-risk individuals. RESEARCH DESIGN AND METHODS: We studied the 1,244 TrialNet Pathway to Prevention study participants (T1D patients' relatives without diabetes and with one or more positive autoantibodies) who were genotyped with Illumina ImmunoChip (median [range] age at...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30002199
DOI: 10.2337/dc18-0087
PMCID: PMC6105323

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