Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Intact expression status of RASSF1A in acute myeloid leukemia.

Medical oncology (Northwood, London, England) - 1 Jan 2014

Zare-Abdollahi Davood, Safari Shamsi, Movafagh Abolfazl, Ghadiani Mojtaba, Riazi-Isfahani Sahand, Omrani Mir Davood

Abstract excerpt

As a typical tumor suppressor gene, transcriptional silencing of ras-association domain family 1, isoform A (RASSF1A) is caused by biallelic methylation or the condition that one allele is methylated and then the other allele lost by allelic loss, as second hit. RASSF1A is inactivated epigenetically and thus down-regulated in many solid tumors. In summary, for the first time, we analyzed the expression status of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease Progression
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Leukemic

Share to Gene Silencing

Share to Genes, Tumor Suppressor

Share to Leukemia, Myeloid, Acute

Share to Protein Isoforms

Share to Tumor Suppressor Proteins

Source

Identifiers

PMID: 24248815
DOI: 10.1007/s12032-013-0770-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Intact expression status of RASSF1A in acute myeloid leukemia.PMID 24248815Read ↗

The tumor suppressor RASSF1A in human carcinogenesis: an update.Semantic proximity Read ↗

The novel RASSF6 and RASSF10 candidate tumour suppressor genes are frequently epigenetically inactivated in childhood leukaemiasSemantic proximity Read ↗

Inactivation of the RASSF1A in osteosarcoma.Semantic proximity Read ↗

Frequent epigenetic inactivation of the RASSF1A tumour suppressor gene in testicular tumours and distinct methylation profiles of seminoma and nonseminoma testicular germ cell tumoursSemantic proximity Read ↗

RASSF1A gene inactivation in non-small cell lung cancer and its clinical implication.Semantic proximity Read ↗

Quantitative detection of RASSF1A DNA promoter methylation in tumors and serum of patients with serous epithelial ovarian cancer.Semantic proximity Read ↗

Hypermethylation of the cpG island of Ras association domain family 1A (RASSF1A), a putative tumor suppressor gene from the 3p21.3 locus, occurs in a large percentage of human breast cancers.Semantic proximity Read ↗

Quantitative aberrations of hypermethylated <i>RASSF1A</i> gene sequences in maternal plasma in pre‐eclampsiaSemantic proximity Read ↗

Epigenetic inactivation of secreted Frizzled‐related proteins in acute myeloid leukaemiaSemantic proximity Read ↗

Repression of vascular endothelial growth factor expression by the runt-related transcription factor 1 in acute myeloid leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.