Article
Preferred features of a fluorine-19 MRI probe for amyloid detection in the brain.
Journal of Alzheimer's disease : JAD - 1 Jan 2014
Yanagisawa Daijiro, Taguchi Hiroyasu, Ibrahim Nor Faeizah, Morikawa Shigehiro, Shiino Akihiko, Inubushi Toshiro, Hirao Koichi, Shirai Nobuaki, Sogabe Takayuki, Tooyama Ikuo
Abstract excerpt
Fluorine-19 magnetic resonance imaging (19F MRI) could be a promising approach for imaging amyloid deposition in the brain. However, the required features of a 19F MRI probe for amyloid detection remain unclear. In the present study, we investigated a series of compounds as potent 19F probes that could prevent the reduction in MR signal when bound to amyloid plaques in the brain. Each compound consists of...
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