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<i>In vivo</i> detection of amyloid plaques in a mouse model of Alzheimer's disease

20 Jun 2000

Abstract excerpt

Strategies for treating Alzheimer's disease (AD) include therapies designed to decrease senile plaque (SP) formation and/or promote clearance of SPs, but clinical trials of these treatments are limited by the lack of effective methods to monitor changes in plaque burden in the brains of living AD patients. However, because SPs are extracellular deposits of amyloid-beta peptides (Abeta), it may be possible to...

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PMID: 10861023
DOI: 10.1073/pnas.97.13.7609

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