Article

Protonation-Guided Design and Evaluation of Selective PET Tracers for Light Chain Cardiac Amyloidosis

2026-02-03

Abstract excerpt

<title>Abstract</title> <p> Early detection of cardiac amyloidosis (CA) is challenging, despite advances in repurposed <italic>β</italic> -amyloid PET tracers and amyloid-targeted [ <sup>124</sup> I]Evuzamitide. The heterogeneity of CA subtypes requires invasive tests, like tissue biopsy, before targeted therapy can begin. Amyloidogenic light chains (AL) expose negatively charged pockets enriched in acidic r...

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Literature Corpus work: 179c93fc-cc1a-5009-bcf7-3ad937df6b9c
DOI: 10.21203/rs.3.rs-7823866/v1

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