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Article

Mathematical modeling of cell population dynamics in the colonic crypt and in colorectal cancer.

Proceedings of the National Academy of Sciences of the United States of America - 6 Mar 2007

Johnston Matthew D, Edwards Carina M, Bodmer Walter F, Maini Philip K, Chapman S Jonathan

Abstract excerpt

Colorectal cancer is initiated in colonic crypts. A succession of genetic mutations or epigenetic changes can lead to homeostasis in the crypt being overcome, and subsequent unbounded growth. We consider the dynamics of a single colorectal crypt by using a compartmental approach [Tomlinson IPM, Bodmer WF (1995) Proc Natl Acad Sci USA 92:], which accounts for populations of stem cells, differentiated cells, and...

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Identifiers

PMID: 17360468
DOI: 10.1073/pnas.0611179104
PMCID: PMC1820699

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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