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Article

A multiplex SNaPshot assay as a rapid method for detecting KRAS and BRAF mutations in advanced colorectal cancers.

The Journal of molecular diagnostics : JMD - 1 Sept 2011

Magnin Sandrine, Viel Erika, Baraquin Alice, Valmary-Degano Severine, Kantelip Bernadette, Pretet Jean-Luc, Mougin Christiane, Bigand Marthe, Girardo Benoît, Borg Christophe, Ferrand Christophe

Abstract excerpt

The analysis of KRAS mutations has become a prerequisite for anti-epidermal growth factor receptor therapy in patients with metastatic colorectal cancers. KRAS mutations are associated with resistance to treatment by monoclonal antibodies such as cetuximab and panitumumab and thus are correlated...

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Source

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Identifiers

PMID: 21742054
DOI: 10.1016/j.jmoldx.2011.05.010
PMCID: PMC3157611

Genes

KRAS
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21742054-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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A multiplex SNaPshot assay as a rapid method for detecting KRAS and BRAF mutations in advanced colorectal cancers.PMID 21742054Read ↗

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COLD-PCR enhanced melting curve analysis improves diagnostic accuracy for KRAS mutations in colorectal carcinomaSemantic proximity Read ↗

Diagnostic accuracy of high resolution melting analysis for detection of KRAS mutations: a systematic review and meta-analysis.Semantic proximity Read ↗

A PNA-mediated clamping PCR for routine detection of KRAS mutations in colorectal carcinoma.Semantic proximity Read ↗

Validation of a Multiplex Allele-Specific Polymerase Chain Reaction Assay for Detection of KRAS Gene Mutations in Formalin-Fixed, Paraffin-Embedded Tissues from Colorectal Cancer Patients.Semantic proximity Read ↗

Comparison of Sanger sequencing, pyrosequencing, and melting curve analysis for the detection of KRAS mutations: diagnostic and clinical implications.Semantic proximity Read ↗

Detection of KRAS codon 12 and 13 mutations by mutant-enriched PCR assay.Semantic proximity Read ↗

Multi-Center Evaluation of the Fully Automated PCR-Based Idylla™ KRAS Mutation Assay for Rapid KRAS Mutation Status Determination on Formalin-Fixed Paraffin-Embedded Tissue of Human Colorectal CancerSemantic proximity Read ↗

SNaPshot and StripAssay as valuable alternatives to direct sequencing for KRAS mutation detection in colon cancer routine diagnostics.Semantic proximity Read ↗

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