Article
Pediatric brainstem gangliogliomas show BRAF(V600E) mutation in a high percentage of cases.
Brain pathology (Zurich, Switzerland) - 1 Mar 2014
Donson Andrew M, Kleinschmidt-DeMasters Bette K, Aisner Dara L, Bemis Lynne T, Birks Diane K, Levy Jean M Mulcahy, Smith Amy A, Handler Michael H, Foreman Nicholas K, Rush Sarah Z
Abstract excerpt
Brainstem gangliogliomas (GGs), often cannot be resected, have a much poorer prognosis than those located in more common supratentorial sites and may benefit from novel therapeutic approaches. Therapeutically targetable BRAF c.1799T>A (p.V600E) (BRAF(V600E) ) mutations are harbored in roughly 50% of collective GGs taken from all anatomical sites. Large numbers of pediatric brainstem GGs, however, have not been...
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