BRAF-V600E immunohistochemistry in a large series of glial and glial-neuronal tumors.

doi:10.1002/brb3.641

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Article

BRAF-V600E immunohistochemistry in a large series of glial and glial-neuronal tumors.

Brain and behavior - 1 Mar 2017

Breton Quentin, Plouhinec Hélène, Prunier-Mirebeau Delphine, Boisselier Blandine, Michalak Sophie, Menei Philippe, Rousseau Audrey

Abstract excerpt

INTRODUCTION: Some glial-neuronal tumors (GNT) (pleomorphic xantho-astrocytoma [PXA], ganglioglioma [GG]) display BRAF-V600E mutation, which represents a diagnostic clue to these entities. Targeted therapies against BRAF-V600 protein have shown promising results in GNT. The aim of this study was to assess the utility of BRAF-V600E immunohistochemistry (IHC, clone VE1) in daily practice in a series of 140 glial,...

Topics

Adolescent
Adult
Aged
Central Nervous System Neoplasms
Child
Child, Preschool
Female
Glioma
Humans
Immunohistochemistry
Infant

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Mutation

Proto-Oncogene Proteins B-raf

Real-Time Polymerase Chain Reaction

Sensitivity and Specificity

Sequence Analysis, DNA

Source

Open in PubMed Open full text

Identifiers

PMID: 28293477
DOI: 10.1002/brb3.641
PMCID: PMC5346524

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-28293477-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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