Article
Detection of BRAF V600E Mutation in Ganglioglioma and Pilocytic Astrocytoma by Immunohistochemistry and Real-Time PCR-Based Idylla Test.
Disease markers - 1 Jan 2020
Durślewicz Justyna, Klimaszewska-Wiśniewska Anna, Antosik Paulina, Kasperska Anna, Grzanka Dariusz, Szylberg Tadeusz, Szylberg Łukasz
Abstract excerpt
The BRAF V600E mutation is an important oncological target in certain central nervous system (CNS) tumors, for which a possible application of BRAF-targeted therapy grows continuously. In the present study, we aim to determine the prevalence of BRAF V600E mutations in a series of ganglioglioma (GG) and pilocytic astrocytoma (PA) cases. Simultaneously, we decided to verify whether the combination of fully...
Topics
- Adolescent
- Adult
- Aged
- Astrocytoma
- Automation, Laboratory
- Brain Neoplasms
- Child
- Female
- Ganglioglioma
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Mutation